1. download & install SIP https://www.riverbankcomputing.com/software/sip/download https://gist.github.com/kilfu0701/47b74a17a70b43549985 or $ brew upgrade sip 2. Upgrade QT $ brew upgrade qt 3. download PyQt5 https://www.riverbankcomputing.com/software/pyqt/download5 check the path of the modules $ python configure.py -d /usr/local/lib/python2.7/site-packages/ --qmake=/usr/local/Cellar/qt/5.9.1/bin/qmake --sip=/usr/local/Cellar/python/2.7.13/Frameworks/Python.framework/Versions/2.7/bin/sip --sip-incdir=../sip-4.19.3/siplib $ make $ sudo make install 20170-10-22 Updated if PyCharm has no reference to PyQt, check the preferences, find the python package folder structure and change the directory(-d /Library/Python/2.7/site-packages)
artilla's personal blog. Sorry for broken English, just in practice